Researchers have found that cerebrospinal fluid (CSF) pressure was a third lower in patients with primary open-angle glaucoma than in those who did not have the condition. The group of researchers led by John Berdahl also found in a retrospective case-control study that intraocular pressure (IOP) was similar between patients with glaucoma and those with other vision defects. The research published in the May issue of Ophthalmology suggests that the pressure difference between the intraocular space and the CSF space, the so-called translaminar pressure difference, may play a role in the pathogenesis of glaucoma.